Productus
Di-Tert, BUTYL dicarbonate; Cas No.: 24424-99-5
Synonyma: bis (Tert, butoxycarbonyl) cadmiae; boc (II) o CPD; Boc2o CPD, Di-Tert-Butyl Dicarbonate, Di-Butyl Pyrocarbonate; Di-Tert-Butyl
Di-Tert-Butyl DiCarbonate
● species / color: albo ad off-album microcrystalline pulveris
● Vapor Press: 0.7MMHG ad XXV ° C
● Melting Point: 22-24 ° C
● Refractive Index: 1.4090
● ferveret Point: 235,8 ° C ad DCCLX Mmhg
● Flash Point: 103.7 ° C
● Psa:61.83000
● Density: 1.054 G / CM3
● Listp: 2.87320
● PRAECLUSIO TEMP.:2-8M
● sensitive.:Moisture sensitivo
● aqua Solubility.:Miscible cum Decalin, Toluene, Carbon Tetrachloride, Tetrahydrofuran, Dioxane, Alcohols, Acetone, Acathetro et Dimethylform
● Xlogp3: 2.7
● hydrogenii vinculum donator comitem: 0
● Hydrogenium Bond Body comitem: V
● Rotatable vinculum comitem: VI
● Missam: 218.11542367
● Gravis Atom comitem: XV
● Complexity: CCXVIII
Notitia safty
● Picogram (s):
T, T +,
F, F +,
XI
● Hazart Codes: T +, T, F, XI, F +
● statements: 11-19-26-36 / XXXVII / 38-43-10-40
● Salutis statements: 16-26-28-36 / 37-45-7 / 9-37 / 39-24-36 / XXXVII / 39-33
Utilis
Euge classes:Alii Classes -> Esters, Alius
Canonica ridet:C (c) (c) O (= o) O (o =) O (c) (C) C
Usus:Di-Tert-Butyl Dicarbonate (Boc2o) est late usus Reagent enim introducendis protegens coetus in peptide synthesis. Is ludit magna munus in praeparatione VI-Acyll, 1,2,3,4, tetrahydropyridine per reagens cum II Piperidone. Serves ut protegens coetus in solidum tempus peptide synthesis.
Detailed introductio
Di-Tert, Butyl Dicarbonateest reagentem in organicum synthesim. Est etiam notus ut T-Boc anhydride et boc anhydride. Est communiter ad protegendum Amine eget coetus durante chemical reactiones. Di-Tert-BUTYL dicarbonate Reacts cum amines ad formam carbamate derivationes, providing temporalis praesidio pro Amine Group. Cum autem desideravit reactionem est completum, in carbamate coetus potest facile remota per curatio cum acidum, pomiferum faciens originale Amine functionality. Hoc est utilis belli ad selectas modificat quaedam eget coetus in organicum moleculis.
Applicatio
In addition ut protegens Amine Groups, Di-Tert-Butyl Dicarbonate habet variis aliis applications in organicum synthesim:
Tutela of Hydroxyl Group:Di-Tert, BUTYL dicarbonate potest agere cum alcohols ad formare carbonates, protegens hydroxyl coetus. Et carbonate coetus potest igitur remota usura oportet condiciones, permittens ad selectivam modificatio aliarum eget coetus.
Carbonylation reactiones:Di-Tert-BUTYL dicarbonate potest esse sicut fons carbo Monoxide in carbonylation reactiones. Hoc reagit cum nucleophailes ut amines, alcohols et thiols ad formare carbonylated products.
Praeparatio acidum chlorides:Reagens di-Tert-BUTYL dicarbonate cum thionyl chloride aut oxalyl chloride cedit correspondentes acid chlorides. Acidum chlorides sunt versatile reagentia in variis synthetica transformations.
Firmus-Phase peptide synthesis:Di-Tert-BUTYL dicarbonate est communiter in praesidio et Deprotection Steps in solidum, tempus peptide synthesis. Est solebat praesidio amino acida durante catena extensio et removere protegens coetibus ad exponere Amino coetus ad subsequentem iungere reactiones.
Polymerization Reactiones:Di-Tert, BUTYL dicarbonate potest agere ut catena transitus agente in polymerization profectae. Potest agere cum crescente polymer vincula, terminans eorum incrementum aut generating novus reactive sites.
Hi sunt pauci exempla de multis applications di-Tert-butyl Dicarbonate in organicum synthesis. Eius versatility et otium of usu faciunt ea valuable Reagent in variis eget mutatio.
