N-Methyl-2-pyrrolidone

Description:

Product nomen:N-Methyl-2-pyrrolidone

Synonyma:M-PYROL(R);1-Methyl-2-pyrrolidinone(99.5%, HyDry, Water≤50 ppm (by KF)); 1-Methyl-2-pyrrolidinone(99.5%, HyDry, cum cribris hypotheticis, Water≤50 ppm (per KF)); N-METHYL-2-PYRROLIDONE; 1-METHYL-2-PYRROLIDONE, REAGENT(ACS)1-METHYL-2-PYRROLIDONE, REAGENT (ACS)1-METHYL-2-PYRROLIDONE, REAGENT (ACS) ACS);1-Methyl-2-pyrrolidinone 872-50-4 NMP N-Methyl-2-pyrrolidinone;

CAS;872-50-4

MF:C5H9NO

MW:99.13

EINECS:212-828-1

Categoria:NMP; Donec rudis materiae, UV / Vis); GC Headspace Solvents; GC Solvents, Solvents pro GC applicationes; ACS et Reagent Grade Solvents; ACS Grade, ACS Grade Solvents; Carbon Ferro cann cum NPT Threads; Metalla gravis, Solventa ad LC- ICP-MS, Toxins (praeter pesticide / medicamento residua); Applications, Potus Analysis; Aedificium obstruit; C4 ad C8; Chemical Synthesis, Food &; GC-MS Solvents, Heterocyclic Aedificium obstruit; ICP-OES / -MS, Pyrrolidines; Reagentia ad Inorganicum Trace Analysis; Solvents pro Metal Speciation Analysis; Solventium Speciationis Analysis (LC-ICP-MS); Spectroscopia; Vestigium Analysis Reagentium &; Anhydrous, Products; Applicatio;Alternativa Energy;Amber Vitri Utres; Analytica Reagentia; Analytica / chromatographia; CHROMASOLV Plus; Chromatographia Reagentis &;Electrolytes;HPLC &;HPLC Plus Grade Solvents (CHROMASOLV); Organicum Solventium, Semi-Bolk Solvents, Solvent Utres, Solvent Packaging Options, UHPLC Solvents (CHROMASOLV); NMR; Spectrophotometric Grade, Spectrophotometric Solvents, Spectroscopia Solvents (IR; Returnable Containers, Certus / Sigillum BottlestechSolventitechn Certus / Sigillum?Utres, 872-50-4; bc0001

Mol fasciculi:872-50-4.

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Pyrrolidone Chemical Properties

Liquescens punctum	-25 °F (lit.)
Ferveret	202 °C (lit.) 82-82 °C/0 mmHg (lit.)
density	1.028 g/mL ad 25 °C (lit.)
vapor density	3.4 (vs. aere);
vapor pressura	0.29 mm Hg (20 °C)
refractivus index	n20/D 1.479
Fp	87 °F
repono temp.	Copia ad +5°C ad +30°C.
solubility	ethanol: miscible0.1ML/mL, lucidum, sine colore (10%, v/v)
forma	Liquid
pka	-0.41±0.20 (Predicta)
color	≤20(APHA)
PH	8.5-10.0 (100g/l, H2O, 20℃)
Odor	Amine tenuis odor
PH Range	7.7 - 8.0
explosive modum	1.3-9.5%(V)
Aqua Solubility	>=10 g/100 mL ad 20 C
Sensitiva	Hygroscopic
λmax	283nm(MeOH)(lit.)
Merck	14,6117
BRN	106420
Stabilitas:	Stabilis, sed in nudatione putrescit lucem.Combustible.Compatible cum validis oxidizing agentibus, acida fortis, agentibus reducendis, basibus.
InChIKey	SECXISVLQFMRJM-UHFFFAOYSA-N
LogP	-0.46 at 25℃
CAS Reference	872-50-4 (CAS Reference)
NIST Chemia Reference	2-Pyrrolidinone, 1-methyl-(872-50-4)
EPA Substantia Registry System	N-Methyl-2-pyrrolidone (872-50-4)

Salus Information

Periculum Codes	T,Xi
Periculum Denunciationes	45-65-36/38-36/37/38-61-10-46
Salus Denunciationes	41-45-53-62-26
WGK Germania	1
RTECS	UY5790000
F	3-8-10
Autoignition Temperature	84 °F
TSCA	Y
HS Code*	2933199090
Ancipitia substantiae Data	872-50-4 (Ancipitium substantiarum data);
Toxicity	LD50 viva voce in Rabbit: 3598 mg/kg LD50 dermal cuniculus 8000 mg/kg

Pyrrolidone Synthesis Synthesis

Chemical Properties	N-Methyl-2-pyrrolidone hyalina est ad lucem luteam liquidam pellucidam cum levi ammoniaci odoris.N-Methyl-2-pyrrolidone cum aqua omnino miscibilis est.Valde solutum est in alcohols inferioribus, in ketonibus inferioribus, aethere, ethyl, acetate, chloroformi, et benzene et modice solutum in hydrocarbonibus aliphaticis.N-Methyl-2-pyrrolidone valde hygroscopica, chemica stabilis, ad chalybem carbonis et aluminium non corrosiva, et cupro leviter mordax est.Habet humilitatem adhaesivam, firmitatem chemicam et scelerisque validam, altam verticitatem, et humilem volatilitatem.Productum hoc leviter toxicum est, et terminus permissus concentratio in aere 100ppm est. N-Methyl-2-pyrrolidone solvens usus est in variis industriis et applicationibus, ut pingere et tunicas remotionis, processus petrochemici, machinamenta plastica tunicarum, oeconomiae agriculturae, electronic purgatio et industrialis/domestica purgatio.
usus	N-Methyl-2-pyrrolidone (NMP) polaris aprotica solvens est quae utilitates habet toxicitatis humilis, punctum fervens altum, solvency praestans, valida selectivity et bonae stabilitatis.In purgatione hydrocarboni aromatici, extractionis, acetylenae, olefins, et diolefins late usus est. In purgatione industriae adhibetur, et solvendo inservit ad productiones pesticidas, materias materias, tunicas, fibras syntheticas et ambitus integrales. Potest etiam adhiberi ut purgator industrialis, dispersus, fucus, ducatus et antifreeze. N-Methyl-2-pyrrolidone optima solvendo est, late in extractione aromatum adhibita, oleum lubricabile expolitio, locupletatio acetylene, butadiene separatio et synthesis gasi desulfurizationis. Usus est in gas desulfurizatione, lubrica oleum expolitio, oleum antifreeze lubricatio, olefin extractio, et quasi solvens ad insolubilem machinationem materiarum materiarum polymerizationem. Adhiberi potest in herbicide, ad materias insulationes mundandas, semiconductoris industriae praecisionem instrumentorum et tabularum ambitum, ad redivivum PVC exhauriendum, sicut purgat, tingunt supplementum et agentis dispersionem. Adhibetur in mediis ad reactiones polymerizationes, quales sunt plasticae machinariae et fibra aramid. N-Methyl-2-pyrrolidone adhibetur ut polyvinylidene fluoride solvens et electrode materia auxiliaris lithium gravidarum ion. summus gradus puritatis pro ICP-MS deprehendatur. Nam peptide synthesis.
toxicity	Oral (mus) LD50:5130 mg/kg; oralis LD50:3914 mg/kg;Dermal (rbt) LD50:8000 mg/kg.
Vastum dispositioni	Con- stat, loci vel nationalis ordinationes pro arbitrio competenti.Dispositio facienda est iuxta normas officiales.Aqua, si opus est, purgandis agentibus.
repono	N-Methyl-2-pyrrolidone hygroscopica est (umorem carpit) sed sub normalibus conditionibus stabilis est.Oppugnabit cum validis oxydizeribus ut hydrogenii peroxidum, acidum nitricum, acidum sulphuricum, etc. Primae compositionis fructus carbonis monoxidi et oxydi nitrogenii fumos efficiunt.Expositio superflua vel profluvium vitanda est in re boni operis.Lyondell Societas Chemical Commendat butylum chirothecas gerens cum usus N-Methyl-2-pyrrolidone.N-Methyl-2-pyrrolidone munda reponenda, phenolico-lineata ferro leni vel tympana mixtura.Teflon®1 et Kalrez®1 demonstratae sunt materias gasket idoneas esse.Quaeso recensere MSDS prior ad tractantem.
Descriptio	N-Methyl-2-pyrrolidone aprotica solvenda est cum amplis applicationibus: processus petrochemicus, superficies vestis, tincturae et pigmenta, compositio purgatio industrialis et domestica, ac formulae agriculturae et pharmaceuticae.Maxime irritamentum est, sed etiam plures casus contactus dermatitis in parva societate electrotechnica effecit.
Chemical Properties	N-Methyl-2-pyrrolidone est liquor hyalinus vel levis luteus cum amine odoris.Plures reactiones chemicae subire potest, etiamsi stabilis idoneus accipitur.hydrolysi sub neutras conditiones resistit, sed fortis acidum vel basim curationi consequitur per foramen ad acidum 4-methyl aminobutyricum.N-Methyl-2-pyrrolidone reduci potest ad 1-methyl pyrrolidinem cum borohydride.Curatio cum agentibus chlorinantibus in media formatione provenit, medium quod ulterius substitutionem subire potest, curatio cum nitrate amyl nitrate reddit.Olefins ad 3 positioni curationis addi potest primum cum esters oxalicis, deinde cum aldehyis congruis (Hort et Anderson 1982).
usus	N-Methyl-2-pyrrolidone polaris solvens est quae in chemia organica et polymerorum chemiae adhibetur.Magnae applicationes includunt receptam et purificationem acetylenarum, olefinium, diolefinum, purificationis gasi, et aromatum extractionem e feedsstocks. N-Methyl-2-pyrrolidone versatile industriae solvens est.NMP nunc pro usu solum in pharmaceuticis veterinariis probatum est.Determinatio dispositionis et metabolismi NMP in rat conferet ad intelligendum toxicologiam huius chemici exogenosi, quem homo in plus ponderis patebit.
usus	Solvetur ad altas resinas temperatus;processus petrochemicus, in microelectronics fabricandi industriam, tincturas et pigmenta, industrialem et domesticam emundationem componit;agriculturae et pharmaceutical formulae
usus	N-Methyl-2-pyrrolidone utilis est ad spectrophotometriam, chromatographiam et ICP-MS detectionem.
Definition	ChEBI: Sodalis classis pyrrolidin-2-quae est pyrrolidin-2-una, in qua hydrogenium nitrogenii adnexum sub yl globo substituitur.
Productio Methodi	N-Methyl-2-pyrrolidone fabricatur per reactionem emptumtrolactonum cum methylamine (Hawley 1977).Alii processus comprehendunt praeparationem per hydrogenationem solutionum acidorum maleicorum vel succinicorum cum methylamine (Hort et Anderson 1982).Manufacturers huius chemica includunt Lachat Chemical, Inc, Mequon, Wisconsin et GAF Corporation, Covert City, California.
Synthesis Reference(s)	Tetraedri Epistolae, XXIV, p.1323, 1983DOI: 10.1016/S0040-4039(00)81646-9
Communia	N-Methyl-2-pyrrolidone (NMP) potens est, aprotica solvens cum magna solvency, et humilis volatilitas.Hic hyalinus, altus fervens, alte mico mucro, et humilis vaporis pressus liquor, mitis aminei similis fert odoris.NMP altam stabilitatem chemicam et scelerisque habet et cum aqua omnibus temperaturis omnino miscibilis est.NMP cum aqua, alcohols, aethereis, ketonibus, et hydrocarbono aromatico/chlorinated co-solvente inservire potest.NMP et recyclabilis per distillationem est et facile biodegradabilis.NMP in Hazardoo Aeris Pollutantis (HAPs) indicem anni 1990 Aeris Tersus Animadversiones non invenitur.
Aer & aqua Reactiones	Solutum in aqua.
Reactividad Profile	Haec aminea est basis chemica valde lenis.N-Methyl-2-pyrrolidone ad corrumpendos acida tendit ad formandum sales plus aquae.Moles caloris, qui per molem aminis in neutralizatione evolvitur, a robore amine tanquam turpi late patet.Amines cum isocyanatis, organicis halogenatis, peroxidis, phenolis (acidicis), epoxidis, anhydridis, et halidis acidis repugnare possunt.Consectetarium gaseum flammabile generatur ab abamine in compositione cum agentibus validis reducendis, ut hydrides.
Discrimen	Gravi cute et oculis irritamentum.Explosive lim-eius 2.2-12.2%.
Periculum salutis	Inhalatio vaporum calidorum naribus et faucibus irritare potest.Insecta rodit oris et stomachi.Contactus oculis rodit.Repetita et diuturna cutis contactum lenem efficit irritationem caducam.
Ignis Discrimen	Periculosas speciales Combustionis Products: Oxydi toxici nitrogenis in igne formari possunt.
Flammability et Explosibilitas	Nonflammable
Industriae usus	1) N-Methyl-2-pyrrolidone adhibetur ut dipolaris generalis aprotica, solvens, stabilis et irrevocabilis; 2) hydrocarbonum aromaticum ad extractionem unguentorum lubricantium; 3) ad remotionem dioxidis carbonis in generantibus ammoniaci; 4) ut solvendo ad polymerizationem profectae et polymerorum; 5) quasi DENUDATOR PINGUIS; 6) pro pesticide formulae (USEPA 1985). Alii usus non-industriales N-Methyl-2-pyrrolidone fundantur suis proprietatibus quasi dissociationem solvendo aptam studiis chemicis electrochemicis et physicis (Langan et Salman 1987).Applicationes pharmaceuticae proprietates N-Methyl-2-pyrrolidones adhibent ut penetrationem augentem ad celeriorem translationem substantiarum per cutem (Kydoniieus 1987; Barry et Bennett 1987; Akhter et Barry 1987).N-Methyl-2-pyrrolidone probata est ut solvens applicationis slimicidium ad materiae sarcinas escas (USDA 1986).
Contactus allergens	N-Methyl-2-pyrrolidone aprotica solvenda est cum amplis applicationibus: processus petrochemicus, superficies vestis, tincturae et pigmenta, compositio purgatio industrialis et domestica, ac formulae agriculturae et pharmaceuticae.Maxime irritamentum est, sed gravem contactum dermatitis ob diuturnam contactum causare potest.
salus Profile	Venenum per viam intravenous.Mediocriter toxici per ingestionem et vias intraperitoneales.Leniter toxici per contactum cutis.teratogen experimentale.Effectus generationis experimentalis.Mutatio notitia relata.Combustible cum exposita calori, flamma aperta, vel oxydizeri potens.Ad ignem, utere spuma, CO2, arida chemica.NOx calefactus in compositione fumos toxicos emittit.
Carcinogenicity	Mures pyrrolidones vapori N-Methyl-2-pyrrolidone expositi sunt ad 0, 0.04, vel 0,4 mg/L pro 6 h/die, 5 diebus/ebdomadis per 2 annos.Male mures in 0.4 mg/L corpus medium pondus modice imminutum ostendit.Nulla vitae brevior toxici vel carcinogenici effectus observabantur in muribus expositis per 2 annos vel 0.04 vel 0.4mg/L ipsius N-Methyl-2-pyrrolidone.Per viam dermal, globus 32 murium initiationis dosis 25 mg of N-Methyl-2-pyrrolidone secuta est post 2 septimanas per applicationes phorboli myristatis acetatis fautoris tumoris, ter in hebdomada, plus quam 25 septimanas.Dimethylcarbamoyl chloridi et dimethylbenzanthracene pro positivis moderatoribus servierunt.Etsi coetus N-Methyl-2-pyrrolidones tres tumores cutaneas habuit, haec responsio non significans considerata est comparata cum positivis moderatoribus.
Semita metabolicae	Mures radio-intitulatum N-methyl-2- pyrrolidinonem administrant (NMP), et maior via excretionis per mures est per urinam.Maior metabolita, quae 70-75% dosis administrati repraesentatur, est 4-(methylamino) acidum butenoicum.Productum integrum hoc unsaturatum ex eliminatione aquae formari potest, et coetus hydroxylis in metabolite prior hydrolysi acido adesse potest.
Metabolismus	Mures masculi Sprague-Dawley datae sunt una iniectio intraperitonea (45 mg/kg) radiolabellorum 1 -methyl-2-pyrrolidone.Plasma gradus radioactivitatis et compositi per sex horas monita sunt et eventus suggesserunt celeri distributione quae secuta est per tempus lentum eliminationis.Maior copia pittacii intra 12 horas in urina excernitur et circiter 75% dosis intitulati aestimatur.Post viginti quattuor horas dosis excretio cumulativa erat circiter 80% dosi.Usus tam anulus quam methyl-intitulatus, tum uterque.¹⁴C]- et [3H] intitulatum l-methyl-2-pyrrolidone.Rationes intitulatae initiales primis VI horis post dosis conservatae sunt.Post sex horas iecur et intestina inventa sunt summas collectiones radioactivitatis continentes, circiter 2-4% dosi.Parva radioactivity notata est in bile vel aere respirato.Princeps effectus liquoris chromatographiae urinae praesentiam unius maioris et duarum minorum metabolitarum ostendit.Maior metabolita (70-75% dosis radioactivae administrati) per liquidum chromatographiam massam spectrometriam et chromatographiam massam spectrometriae gasi resolvitur et proponitur ut 3- vel 5-hydroxy-l-methyl-2-pyrrolidone (Well. 1987).
Purificationis Methodi	Excoquatur pyrrolidone subtrahendo aquam sicut benzene azeotrope.Fractive distillat ad 10 torr per 100-cm columnam helices vitreis refertam.[Adelman J Org Chem 29 1837 1964, McElvain & Vozza J Am Chem Soc 71 896 1949.] Hydrochloridum habet m 86-88o (ab EtOH vel Me2CO/EtOH) [Reppe et al.Justus Liebigs Ann Chem 596 1 1955].[Beilstein 21 II 213, 21 III/IV 3145, 21/6 V 321.]